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Cellular Solutions for Clinical Challenges
Proceedings of the 21st ESACT Meeting (Dublin)
Edited by Nigel Jenkins, Niall Barron and Paula Alves
The 21st ESACT meeting – ‘Cellular Solutions for Clinical Challenges’ outlined the novel capabilities of animal cell technology to move towards the clinic. The highly successful meeting was attended by a record number of researchers and engineers interested in all aspects of animal cell technology. The meeting included sessions on Stem Cells, Tissue Engineering, Advances in Bioprocessing, Biotherapeutics, Novel Vaccines and Virology and Advances in Synthetic and Molecular Biology. The meeting was supported by an array of exceptional invited speakers from around the world whose contributions complemented the emerging technologies and the challenges facing the clinical application of animal cell culture and technologies. The proceedings here include the short papers, adding to the wealth of knowledge gained from previous ESACT meetings.
Hardcover, ISBN 978-94-007-0883-9, 2009, Springer
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Cells and Culture
Proceedings of the 20th ESACT Meeting (Dresden)
Edited by Thomas Noll
It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.
Hardcover, ISBN 978-90-481-3418-2, 2007, Springer
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Cell Technology for Cell Products
Proceedings of the 19th ESACT Meeting (Harrogate)
Edited by Rodney Smith
The 19th ESACT meeting was to highlight the novel capabilities
of the industry to move the products towards the clinic and
was attended by a wide range of workers in the industry and
for many it was their first ESACT meeting. The meeting was
started with a session on Transcription to Secretion with
a notable set of presentations on the emerging issues. The
other sessions that followed Therapeutic Cell Engineering,
Gene Medicine, Cells to Tissue, Protein products and Process
Technology guided the delegates through the advances made
for the progression of the biotechnology towards the industrial
application of the products from cells. The meeting was supported
by some exceptional invited speakers from around the world
whose contributions complemented the emerging technologies
and the changes being made at the industrial end of the ESACT
spectrum. The proceedings here include the short papers adding
the knowledge of the previous meetings and provide a reference
for the researcher entering, or continuing in the field of
Animal Cell Technology.
Hardcover, ISBN: 978-1-4020-5475-4, 2005, Springer
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Animal
Cell Technology meets Genomics
Proceedings of the 18th ESACT Meeting (Granada)
Edited by F. Godia and M. Fussenegger
The 18th ESACT meeting was celebrated in Granada (Spain)
in May 2003, and was entitled "Animal Cell Technology
Meets Genomics", in order to reflect that the emerging
technologies in the area of genomics, proteomics and other
"-omics"-type disciplines will provide key technological
assets to increase knowledge and open new horizons in animal
cell technology. During the meeting a variety of top-class
emerging technologies were presented together with the lastest
advances in more mature industrial areas. The meeting was
opened by a first session devoted to the understanding of
basic cellular mechanisms, and four sessions focused on applied
aspects of animal cell technology: Cell-based therapies and
gene-based therapies, target discovery and biopharmaceuticals.
The Granada Meeting has also seen a special focus on forefront
industrial case studies. The spirit and scientific excellence
of the 18th ESACT meeting is now reflected in different chapters
of the book. The book presents, in form of short papers, a
high number of the contributions to the meeting, and has been
prepared with the aim to provide a relevant reference of the
current research efforts in Animal Cell Technology.
Hardcover, ISBN 978-4020-2791-5, 2003, Springer
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Animal
Cell Technology: From Target to Market
Proceedings of the 17th ESACT Meeting (Tylosand)
Edited by E. Lindner-Olsson, N. Chatzissavidou and E. Lüllau
This book is the lasting product, a resource of up-to-date information in the scientific literature for the field of animal cell technology, as it was presented during a pleasant and stimulating meeting in Tylösand, Sweden, in June 2001. The title of the meeting, From Target to Market, indicates the usefulness of Animal Cell Technology during all steps in the pharmaceutical development process. Following the biotech products reaching the market, it shows an upward trend in the contribution of biotech products to total New Molecular Entity output in the nineties, which continued until 1996 when biotech represented 25% of the annual output. Since then the proportion has been decreasing.
A perceived hurdle from a market perspective is that a protein per definition is biodegradable and thus requires intravenous, or for some drugs subcutaneous administration. New promising administration technologies such as pulmonary delivery were highlighted at this meeting.
The emphasis on project selection prior to entry in the development phase has triggered a portfolio management using more extensive preclinical data before a development decision is taken. Animal cells have become a very important tool in the drug discovery process. The next generation of products will evolve from applications such as gene therapy, novel vaccines, cell therapy, and gene regulation.
Animal cell technology has a major role to play in the post-sequence era.
Hardcover, ISBN 1-4020-0264-5, 2002, Springer
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Animal
Cell Technology: Products from Cells, Cells as Products
Proceedings of the 16th ESACT Meeting (Lugano)
Edited by A Bernard, B Griffiths, W Noé and F Wurm
This book contains, in the form of concise papers of limited length, the proceedings of the 16th ESACT meeting that was held in Lugano, Switzerland, in April 1999. We hope it will become a useful resource of the most up-to-date information in animal cell technology, at least until the next meeting in 2001.
Classical approaches for the use of animal cells (for example, production of virus vaccines) remain an important technology. However, it appears that major technological advances and major growth are occurring in other areas. Most importantly, protein production on the basis of recombinant DNA molecules transferred into animal cells appears to be an ever-increasing field of interest and innovation.
Increasingly animal cells are being used as substrates for the study of gene activation and repression, and also for the more rapid production of small and moderate quantities of interesting proteins. Tissue engineering, somatic gene/cell therapy, organ-replacement technologies, and cell-based bio-sensors all contribute to a considerable widening of interest and research activity, based on animal cell technology.
Hardcover, ISBN 0-7923-6075-9, 2000, Springer
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Animal Cell Technology: Challenges for the
21st Century
Proceedings of the joint JAACT/ESACT meeting (Kyoto)
Edited
by K. Ikura, M. Nagao, S. Masuda, R. Sasaki.
Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to ascertain their abilities to be used in industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability to produce medically and pharmaceutically, important proteins, and the application of animal cells to gene therapy and artificial organs. This volume gives the readers a complete review of present state of the art in Japan. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working in either academic environments or in biotechnology and pharmaceutical industries.
Hardcover, ISBN 978-0-7923-5805-3, 1999, Springer
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New
Developments and New Applications in Animal Cell Technology
Proceedings of the 15th ESACT Meeting (Tours)
Edited by O-W Merten, P Perrin and B Griffiths
Animal cell technology is becoming an increasingly important part of biotechnology and many products are now used in human health care and for veterinary applications. However, there are many times more products actually in the developmental pipelines of the biotechnology industry, including various phases of clinical trials. The Proceedings of the 15th Meeting of the European Society for Animal Cell Technology (Tours, France, September 1997) presents the actual current state as well as New Developments and Applications in Animal Cell Technology for the benefit of society.
These Proceedings represent both the current state and applications of animal cell technology and the way the technology is expanding into new areas to give a unique insight into new products and applications for human and animal health care.
Hardcover, ISBN 978-0-7923-5016-3, 1998, Springer
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Animal Cell Technology: From Vaccines
to Genetic Medicine
Proceedings of the 14th ESACT Meeting (Vilamoura)
Edited
by Manuel J.T. Carrondo, Bryan Griffiths, José L.P. Moreira
Animal cell technology has undergone a rapid transformation over the last decade from a research tool and highly specialised technology to a central resource for innovation in pharmaceutical research and development. These proceedings of the 14th Meeting of the European Society for Animal Cell Technology (Vilamoura, Portugal, May 1996) bring up to date the historical perspective of animal cell technology for the benefit of society, `From Vaccines to Genetic Medicine', and will charter this vital technology for the years to come.
Strong contributions are grouped in the traditional ESACT areas of 'Cell and Physiology Engineering' dealing with cell state, including genetics, and its environment, and 'Animal Cell Process Engineering' covering integration of bioreaction with bioseparation coupled with on-line monitoring to improve protein production and consistency. Extensive coverage of metabolic engineering on synthesis, folding, assembly, transiting and secretion is dealt with in the session on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. Two traditional but expanding areas of animal cell technology relevance are highlighted in the broad sessions of 'Animal Cells as Tools for Discovery and Testing' and 'Animal Cell Vaccines: Present and Future'. Two sessions finally cover the more recent domains of animal cell technology work - 'Tissue Engineering and Biomedical Devices' and 'Cells and Vectors for Genetic Medicine' - where one can foresee a very bright future.
Hardcover, ISBN 978-0-7923-4321-9, 1997, Springer
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